Bezos family office invests in Profluent Bio’s $106M funding round

Profluent Bio Inc., a biotechnology startup using frontier AI to design novel proteins, has raised $106 million in a Series B round co-led by Bezos Expeditions and Altimeter Capital. Other participants included Spark Capital, Insight Partners, and Air Street Capital. The new capital brings Profluent’s total funding to $150 million. Based in California, Profluent is developing generative AI models that allow scientists to create DNA sequences for custom proteins using natural language prompts. Its proprietary dataset, “Protein Atlas,” includes over 115 billion protein sequences, enabling the company to apply AI scaling laws to molecular design. The company’s open-source genome editor, OpenCRISPR-1, has garnered interest from researchers and pharmaceutical firms. With the new funding, Profluent plans to expand its platform’s capabilities across areas such as therapeutics, biomanufacturing, and agriculture.

About Bezos Expeditions: The Bezos family office

Bezos Expeditions is the private investment firm managing the personal wealth of Amazon founder Jeff Bezos. Established in 2005, the family office oversees investments across technology, space, media, healthcare, and AI. Notable portfolio companies include Twitter, Uber, Airbnb, and Blue Origin, alongside philanthropic initiatives through the Bezos Earth Fund and the Bezos Day One Fund. In the biotech space, Bezos Expeditions has previously invested in companies like GRAIL and Juno Therapeutics. Its co-lead investment in Profluent reflects the family office’s growing focus on programmable biology and the convergence of artificial intelligence with life sciences. As of November 2025, the Bezos family office is one of the most active family offices globally. Recent investments include FieldAI’s $405M funding round, or Synchron’s $200M Series D (as reported in the Top 10 most active US family offices).

Picture Source: Unsplash+ (November 24th, 2025)
Article source: Silicon Angle (November 24th, 2025)